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This is the story of how three men won the Nobel Prize for their research on the humble nematode worm C. elegans; how their extraordinary discovery led to the sequencing of the human genome; how a global multibillion-dollar industry was born; and how the mysteries of life were revealed in a tiny, brainless worm. In 1998 the nematode worm--perhaps the most intensively studied animal on earth--was the first multicellular organism ever to have its genome sequenced and its DNA mapped and read. "When we understand the worm, we will understand life," predicted John Sulston, one of the three Nobel laureates, and his prediction proved astonishingly accurate. Four years later, the research that led to this extraordinary event garnered three scientists a Nobel Prize. Along with Robert Horvitz and Sydney Brenner, Sulston discovered the phenomenon of programmed cell death in the worm, an essential concept that explains how biological development occurs in animal life and, as Horvitz later showed, how it occurs in human life. C. elegans is about as simple as an animal can be, but understanding its genetic organization is helping to reveal the mechanisms of life and, by extension, the mechanisms of our own lives. In the Beginning Was the Worm shows that in order to unlock the secrets of the human genome we must first understand the worm. But this story is about more than just the worm. It is about how an eccentric group of impassioned scientists toiled in near anonymity for years, driven only by a deep passion for knowledge and scientific discovery. It is the story of countless hours of research, immense ambition, and one of the greatest discoveries in human history.… (more)
User reviews
The worm now, is of course, one of the best understood multicellular organisms in all of biology. How it came to be a model organism rivaling the mouse, the fruit fly, and man is an interesting lesson in how science at its best really works. It was a man, Sydney Brenner, with a plan to pick just the right organism that could be used to attack some of the fundamental questions of genetics, development and embryogenesis. The selection of this organism took several years of hard work. It is remarkable that during this start-up of the project, the funding organization, the MRC, supported the work without complaint, even though it was something like five years before publications began to roll out.
The book is written for a general audience, though there is lots here of interest to those who are more acquainted with biology too. The politics and personalities of the effort, now almost fifty years on, are covered in quite a bit of depth and some of it is pretty entertaining. The technical aspects of the research is also explained in enough detail that the reader can follow it pretty easily, though there are a few challenging rough spots too.
This is quite a tale of heroic science getting done with a conviction that unselfish, cooperative, non-commercial, basic research is not only worthwhile, but can be a lot of fun. And these guys clearly had a lot of fun. I think that one of the main reasons, pointed out by the author, was that the researchers were crammed in together with perhaps only a meter of bench space, and often not even a desk, had a lot to do with it. No closed doors, no power point, and no email probably had a lot to do with it too.
The book could have been better organized--the jumping around in time (what decade was this?) sometimes was bothersome to me. The portraits of the scientists were nice to see, but I'd have appreciated some drawings of the worm too. Pictures of the laboratory would have been instructive, I think.
Brown has done a quite respectable job with this book, and I think it is quite worth reading if you have any interest at all in biology or the history of science. The effort described will serve to confound the deconstructionists, mystics and other quacks of the academy for a long time to come.
It's not perfect, a little too simple-minded, but it does a good job of
If one wants to learn something about so obscure a subject, one generally doesn't have much choice; we're lucky the one book on this subject is not bad.